by New research sheds light on a long-standing mystery in the celiac disease community: the exact location where the immune system initiates its reaction to gluten. A team of researchers has made a significant breakthrough in this area, providing crucial insights into the complex workings of the immune response in individuals with celiac disease.
According to recent findings published in the journal “Nature Communications,” the immune system’s response to gluten begins in a specific area of the small intestine called the lamina propria. This discovery challenges the long-held belief that the immune reaction starts in the intestinal epithelium.
The researchers, led by Dr. Alessio Fasano from the University of Maryland School of Medicine, used a combination of techniques, including single-cell RNA sequencing and advanced imaging, to identify the precise location of the immune response. They found that immune cells called T cells and B cells are the primary players in the reaction, and they are located in the lamina propria.
This new understanding of the celiac disease immune response could lead to the development of more effective diagnostic tools and treatments. By targeting the immune cells in the lamina propria, researchers may be able to design therapies that specifically interrupt the immune response, thereby preventing damage to the intestinal tissue.
Further studies are needed to build upon this research and explore the potential implications for celiac disease management. The findings, however, represent an important step forward in understanding the complex mechanisms behind this Autoimmune Disease Treatment.
Researchers from the University of Maryland School of Medicine have identified the lamina propria as the site where the immune system initiates its reaction to gluten in individuals with celiac disease. This discovery challenges previous beliefs and offers new opportunities for the development of diagnostic tools and treatments.
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1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
Money Singh is a seasoned content writer with over four years of experience in the market research sector. Her expertise spans various industries, including food and beverages, biotechnology, chemical and materials, defense and aerospace, consumer goods, etc.
